vol. 1, num. 1, 2003

Dissociation
Dissociative Phenomena. Questions and Answers.

Editors: Mario Di Fiorino and Maria Luisa Figueira

Ketamine Assisted Psychotherapy (Kpt) of Heroin Addiction: Immediate Effects and Twelve Months Follow-Up

Evgeny Krupitsky, Andrey Burakov, Tatyana Romanova, Igor Dunaevsky, Rick Strassman, Nina Grinenko, Alexander Grinenk

Ketamine Assisted Psychotherapy (Kpt) of Heroin Addiction: Immediate Effects and Twelve Months Follow-Up

Summary. Seventy detoxified heroin addicts were randomly assigned to one of two groups: 35 in the experimental group, and 35 in the control. The patients of the experimental group received existentially oriented psychotherapy in combination with a hallucinogenic (“psychedelic”) dose of ketamine (2.0 mg/kg i.m.). The patients of the control group received the same psychotherapy combined with a very low, non-hallucinogenic (non-psychedelic), dose of ketamine (0.2 mg/kg i.m.). This low dose induces some pharmacological effects without inducing a peak psychedelic experience. Both the psycho-therapist and patient were blind to the dose of ketamine. The results of this double blind randomized clinical trial of KPT for heroin addiction showed that high dose KPT produced a significantly greater rate of abstinence in heroin addicts within the first year of follow-up than did low dose KPT. High dose KPT brought about a greater and longer-lasting reduction in craving for heroin, as well as greater positive change in nonverbal unconscious emotional attitudes.


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